Table 2.

Hormonal profile of study subjects

	Young			Older			Young PWS vs. older PWS	Young C vs. older C
	PWS (n = 33)	C (n = 28)	P₁ value	PWS (n = 14)	C (n = 14)	P₂ value	P₃ value	P₄ value
Total ghrelin (pg/ml)	2217·0 (1646·00, 3274·00)	1964·00 (1647·70, 2251·50)	0·11	1468·45 (1145·71, 1619·32)	839·7 (719·8, 889·7)	< 0·001	< 0·001	< 0·001
Leptin (ng/ml)	6·25 (2·83, 7·06)	3·93 (2·65, 5·13)	0·04	31·45 (12·92, 42·67)	32·2 (15·6, 54·5)	0·80	< 0·001	< 0·001
Glucose (mg/dl)	85·10 (76·60, 88·60)	78·80 (74·80, 84·80)	0·05	87·75 (81·75, 101·50)	94·9 (89·0, 99·5)	0·45	0·08	< 0·001
Insulin (μIU/ml)	8·42 (6·30, 10·64)	5·96 (4·88, 7·60)	0·01	13·49 (10·17, 29·38)	23·2 (17·2, 34·7)	0·03	0·002	< 0·001
HOMA-IR	1·62 (1·35, 2·16)	1·19 (0·89, 1·59)	0·01	3·20 (2·49, 5·68)	5·1 (4·1, 8·6)	0·03	0·001	< 0·001
Total adiponectin (ng/ml)	16330·00 (12636·00, 21223·00)	11105·00 (9379·00, 17824·50)	0·03	8769·00 (6363·50, 15045·50)	5798·0 (3216·5, 7352·5)	0·01	0·002	< 0·001
HMW adiponectin (ng/ml)	11342·00 (9208·00, 12725·00)	6826·0 (5610·00, 11610·50)	0·03	5370·50 (2763·00, 11867·50)	2523·3 (819·0, 3147·0)	0·01	0·02	< 0·001
HMW : total adiponectin ratio	0·66 (0·59, 0·78)	0·61 (0·55, 0·69)	0·12	0·71 (0·48, 0·84)	0·40 (0·27, 0·51)	0·03	0·92	0·005
Total adiponectin : leptin ratio	2812·71 (1676·73, 6264·45)	3467·68 (1977·38, 4974·79)	0·61	257·05 (126·49, 1105·55)	132·31 (62·13, 366·18)	0·15	< 0·001	< 0·001
HMW adiponectin : leptin ratio	2812·71 (1676·73, 6264·45)	2150·21 (1195·74, 3536·42)	0·19	172·056 (66·54, 846·29)	59·47 (21·65, 176·12)	0·05	< 0·001	< 0·001

All data are expressed as medians (1st quartile, 3rd quartile); P-values calculated using Wilcoxon rank-sum test.

P₁ = P-value for comparison of young PWS vs. young NC.

P₂ = P-value for comparison of old PWS vs. old NC.

P₃ = P-value for comparison of young PWS vs. older PWS.

P₄ = P-value for comparison of young C vs. older C.