Table 2.

Maternal defense behavior following restraint

Maternal defense	WT (n=10)		CRF2 KO (n=10)		Two Way	RM ANOVA
	Unrestrained	Restrained	Unrestrained	Restrained	Genotype p value	Restraint p value	Interaction p value
Latency to first attack	68.8±16.4	91.4±16.4	119.7±15.0	128.9±15.0	0.292	0.066	0.911
# attacks	15.8±1.1	13.7±1.1	6.1±1.0	5.0±1.0	0.021	0.069	0.054
Total time aggressive	19.7±2.6	19.8±2.6	14.9±2.4	9.1±2.4	0.262	0.128	0.390
Time to first pup	31.7±6.4	37.3±6.3	16.1±5.8	11.4±5.8	0.050	0.944	0.408
Time to fourth pup	76.9±6.6	83.7±6.6	55.3±6.0	53.8±6.0	0.077	0.676	0.508
Time to all pups	842.5±132.4	1051.8±132.4	480.2±120.9	446.2±120.9	0.039	0.494	0.345

Mean (±SEM) time(s) of maternal defense behavior and pup retrieval performed by lactating CRF2 KO and WT dams exposed to mild restraint stress or no restraint. P-values less than 0.05 are shown in bold