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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2008 May 23;1779(9):550–557. doi: 10.1016/j.bbagrm.2008.05.006

Figure 2.

Figure 2

Model of nonstop mRNA degradation in yeast. Transcripts that lack all in-frame termination codons (nonstop mRNAs) cause the translating ribosome to stall at the 3’end of the message. The stalled ribosome is recognized by the C-terminal domain of Ski7p. The N-terminal domain of Ski7p recruits the exosome, providing a physical link between the nonstop mRNA and the exosome, which facilitates rapid degradation of the transcript. Nonstop mRNAs may also be translationally repressed, or the encoded protein may be targeted to the proteasome; however, the significance and mechanisms of these two aspects are not yet clear.