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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2008 May 23;1779(9):550–557. doi: 10.1016/j.bbagrm.2008.05.006

Figure 3.

Figure 3

Model for no-go mRNA decay in yeast. Stem-loop structures, pseudoknots, and rare codons cause the translating ribosome to stall within the coding region of an mRNA. The stalled ribosome is recognized by the Hbs1p/Dom34p complex. Subsequently, the mRNA is cleaved endonucleolytically, generating 5’ and 3’ fragments that are degraded by the exosome and Xrn1p, respectively.