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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2008 May 23;1779(9):550–557. doi: 10.1016/j.bbagrm.2008.05.006

Figure 4.

Figure 4

Unspliced and partially spliced mRNAs are exported and degraded in the cytoplasm. Pre-mRNAs can be exported into the cytoplasm where they are degraded either by nonsense-mediated decay, deadenylation-dependent decapping, or deadenylation-independent decapping. A 3’ splice-defective pre-mRNA containing a lariat structure at its 5’end is debranched in the nucleus by Dbr1p and exported to the cytoplasm where it is degraded by Xrn1p. Alternately, lariat structures can be exported to the cytoplasm and degraded by the exosome.