Table 1.
Summary of results from admixture scans in African Americans with end stage renal disease (ESRD)
| ESRD phenotype |
SNPs | Cases/Controls | Genome Score |
LOD at Chr22 peak |
|---|---|---|---|---|
| All ESRD | 1354 | 1372/806 | 1.67 | 4.55 |
| DM | 1351 | 703/806 | 0.47 | −0.52 |
| Non-DM | 1354 | 669/806 | 5.70* | 8.56 |
| HTN | 1352 | 347/806 | −0.16 | 1.79 |
| FSGS | 1350 | 87/806 | 0.10 | 2.47 |
| GN | 1351 | 126/806 | 0.01 | 1.75 |
| HIV | 1348 | 69/806 | 0.11 | 2.09 |
ESRD=end stage renal disease; DM=diabetic; Non-DM = non-diabetic; FSGS=focal segmental glomerulosclerosis; HTN = hypertensive; GN = glomerulonephritis; HIV=Human immunodeficiency virus nephropathy
Non-DM includes HTN, FSGS, HIV, GN, and 40 cases with other causes
*
Genome scores above 2.0 are considered significant after correcting for multiple comparison on a genome-wide level; scores above 1.0 are suggestive