Table 1.
SFK-Dependent Receptors (SDRs)
| SDR | SFK phosphorylation site(s) a | References |
|---|---|---|
| Multichain immune recognition receptors, e.g., T cell receptor ξ chain, B cell receptor Igα and β chains, FcεRIγ | YXXL/I(6–8 b)YXXL/I | (1–3) |
| Inhibitory immune receptors, e.g., FcεRIIB, SHPS, Siglecs | (I/V/L/S)xYxx(L/V) | (4) |
| Lectins CLEC-2 and Dectin-1 | DEDGYXXL | (5) |
| Ephrin B family | YXXV(3)YXXPXYXXQ(10)YYKV | (6) |
| Nephrin c | Five repeats of YDXV | (7) |
| CDCP1 | YXXI(5)YXXL | (8) |
| Myelin-associated glycoprotein | YAEI | (9) |
| Reelin receptor-Dab1 complexes | YQXI(9)YQXI | (10, 11) |
a
Y, confirmed SFK phosphorylation site; Y, phosphorylation not shown.
b
Numbers in parentheses indicate spacing between sites.
c
Nephrin also binds to SFK SH3 domains.