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. Author manuscript; available in PMC: 2009 Jan 7.
Published in final edited form as: Immunol Rev. 2007 Dec;220:199–213. doi: 10.1111/j.1600-065X.2007.00565.x

Fig. 2. Yin-Yang roles for Foxp3-expressing cells in immune regulation.

Fig. 2

High levels of Foxp3 expression endow T-cell immune suppressive activities to suppress the function of effector T cells and DCs through cell contact-dependent and -independent mechanisms. T cells with high levels of Foxp3 expression promote Th17 cell differentiation, potentially through TGF-β. With decreasing Foxp3 expression, T cells can be converted into different types of effector T cells and direct the differentiation of conventional T cells towards different lineages.