(A, B) Huh7 cells were treated with indicated concentration of C75 for 12 hours (hrs) and then spin-infected with HCVpp or VSVpp and incubated for additional 2 days followed by a luciferase assay to quantify virus entry. (C, D) Huh7 cells were transduced with 3 shRNAi lentiviruses (3216, 3218, and 3219) targeting FASN and the control shRNAi virus (Ctrl) respectively. Two days after lentiviral transduction, the cells were spin-infected with HCVpp or VSVpp and further incubated for 48 hrs prior to luciferase assay. Error bars represent standard deviations.