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. 2009 Jan 12;184(1):143–158. doi: 10.1083/jcb.200807176

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Figure 8. — Cell survival pathways are activated in E10.5 Cert^gt/gt embryos. (A) Components of the cell survival pathway p42/44 ERK are strongly activated in the mutant, whereas MAPK components that mediate stress-mediated response are suppressed. SAPK, stress-activated protein kinase. (B) Components of the apoptotic machinery such as Bak and Bax that also have roles in mediating UPR are activated, whereas antiapoptotic components Bcl-2 and Bcl-x are down-regulated. (C) The total cytochrome c levels in Cert^gt/gt embryos are decreased significantly in the mutant embryos. Although most of the cytochrome c is in the mitochondria in the wild type, in the mutant we see it in both cytosol (C) and mitochondria (M). Also, the increased Bax in Cert^gt/gt embryos is in the cytosol, whereas mitochondrial levels seem unaffected. AIF, apoptosis-induced factor.