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Mdm2-a transgenic mice do not show accelerated aging, but display enhanced senescence in aged tissue. (A) Tissue and total body mass from 3-month-old wild-type (light gray bars) and Mdm2-a (white bars) male mice, and from 20-month-old wild-type (black bars) and Mdm2-a (dark gray bars) male mice. Female mice exhibited the same trend (data not shown). (B) SA-βgal staining of salivary gland tissue from young and aged wild-type and Mdm2-a transgenic mice. Bar, 50 μm.
