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Cytoplasmic p53 in PS1−/− and PS1 ΔE10 neurons translocates to nucleus during oxidative stress. Representative images of NeuN and p53 immunostaining in the presence of cycloheximide, showing that previously synthesized cytoplasmic p53 in PS1−/− and PS1 ΔE10 neurons translocates to the nucleus at 15, 30, and 60 min after treatment with H2O2. Scale bar, 10 μm.
