. 2008 Oct 29;28(44):11421–11431. doi: 10.1523/JNEUROSCI.2873-08.2008

Table 1.

Mouse models for in vivo and neuronal culture studies

Mice	Genotype (color representation)	Objective
Control	PS1^fl/fl; PS2^−/−	Investigate γ-secretase-dependent effects in vivo
PS cDKO	Cre; PS1^fl/fl; PS2^−/−
PS cDKO; hPS1	Cre; PS1^fl/fl; PS2^−/−; hPS1
PS cDKO; D257A	Cre; PS1^fl/fl; PS2^−/−; hPS1D257A
Control	PS1^+/+	Investigate γ-secretase-independent effects in vivo
PS1 ΔE10	PS1^{ΔE10 /ΔE10}
Control	PS1^+/+ or PS1^+/−	Study the mechanisms of γ-secretase-dependent and -independent effects in vitro
PS1^−/−	PS1^−/−
PS1^−/−; hPS1	PS1^−/−; hPS1
PS1^−/−; D257A	PS1^−/−; hPS1D257A
PS1 ΔE10	PS1^{ΔE10 /ΔE10}