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M. tuberculosis biofilms are drug-tolerant. M. tuberculosis mc27000 or the biofilm-defective mc27025 mutant were grown planktonically or as biofilms and treated with either isoniazid (A) or rifampicin (B); the percentages of viable cells remaining after different times of drug treatment are shown. (C) Percentage of surviving cells following 7 day treatment of M. tuberculosis biofilms with antibiotics at different concentrations.
