Table 1.
PySAP1-deficient sporozoites are completely attenuated and do not cause blood-stage infection in BALB/c mice.
| Pysap1(−) | PyWT | |||
|---|---|---|---|---|
| No. of injected sporozoites | Infected | Pre-patent perioda | Infected | Pre-patent perioda |
| 20 | ND | ND | 2/2 | 4 days |
| 100 | ND | ND | 6/6 | 4 days |
| 10 000 | 0/30 | – | 8/8 | 3 days |
| 100 000 | 0/15 | – | 3/3 | 2.5 days |
| 500 000 | 0/8 | – | ND | ND |
| 1 000 000 | 0/4 | – | ND | ND |
| > 2 000 000 | 0/3 | – | ND | ND |
a
The period (in days) between sporozoite infection and the detection of erythrocytic stages in blood smears.
ND, not done.