Figure 5.
Constitutively activated sympathetic nervous system and increased energy expenditure in VGV mice. A, Metabolic rates of wild-type and VGV male mice (6 weeks of age) measured with or without intraperitoneal injection of the β3-AR agonist (CL316243), 5-HT2CR-selective agonist (MK212), or antagonist (SB242084) are presented as the mean ± SEM. No difference in RER was detected (data not shown). B, The β3-AR mRNA levels in BAT. The relative β3-AR mRNA amount is presented as the mean ± SEM. C, The UCP1 mRNA levels in BAT. The relative UCP1 mRNA amount is presented as the mean ± SEM. A–C, Significant differences are indicated by asterisks (*p < 0.05; **p < 0.01). A, #Significantly different from three other values of the wild-type experiments (p < 0.05). ##Significantly different from three other values of the VGV experiments (p < 0.05).