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Toxic effects of 5-HT2CR-selective agonists on VGV mice
| Genotype | MK212 (mg/kg) |
||||||
|---|---|---|---|---|---|---|---|
| 0.2 | 0.3 | 0.5 | 1.0 | 10 | 20 | 50 | |
| Wild type | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 3 (0) | 4 (4) |
| VGV | 0 (0) | 1 (0) | 4 (4) | 4 (4) | 4 (4) | 4 (4) | 4 (4) |
Four each of wild-type and VGV hemizygous males were examined. Indicated are the number of mice that had seizures and, in parentheses, the number of mice that underwent severe convulsions and death.
