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. 2008 Jul 16;28(29):7412–7425. doi: 10.1523/JNEUROSCI.0581-08.2008

Figure 7.

Figure 7.

The effect of block of the glial glycine transporter on the evoked IPSCs. A, Evoked IPSC in control were inhibited by 35%. After wash, ORG-24598 was applied. This resulted in an increase in the amplitude of eIPSCs. Subsequent application of 50 μm SR-95531 resulted in a reduced inhibition of the eIPSC (14% of its value with ORG-24598 alone). The overall effect of ORG-24598 on the amplitude of eIPSC with and without 50 μm SR-95531 is shown in B. Block of the glycine glial transporter strongly reduces the inhibition induced by 50 μm SR-95531, indicating that the transporter has a role in determining the time course of glycine in the cleft. Error bars indicate SDM. C, The average eIPSC in the presence of ORG-24598 (superimposed to the scaled eIPSC in control) has a prolonged decay time that is fitted with a single exponential with time constant of 5.7 ms. D, Application of 50 μm SR-95531 failed to change the decay time in all the cells tested. E, The eIPSCs rise time increased in the presence of ORG-24598 (compare black and dark gray lines) but did not change when 50 μm SR-95531 and ORG-24598 were subsequently applied (G, light gray line). F, Pooled cumulative distribution of rise times for 10 cells (F) and individual values in each experiment (G).