Figure 3.
Population data of THL and O-3841 effects on LTS cell SSI. A, Composite plot of subtracted membrane potential (ΔVm, i.e., the difference in Vm before and after SSI inducing stimuli) in control conditions with 1 μl/ml DMSO in the whole cell pipette (solid circles), and in the presence of THL (open circles) or O-3841 (open triangles). SSI-inducing spike trains indicated by the arrow. Membrane potential measurements were omitted during the spike trains. B, Population data showing membrane conductance (gm) in control (DMSO), or with THL or O-3841 in the whole-cell pipette before (black columns) and 5 min after (white columns) the spike trains. The increase in gm evoked by AP trains in control solution (left graph, **p < 0.01) was blocked by both DAGL inhibitors (middle and right graphs, n.s. = no significant difference; p > 0.05; n = 8 and 7 for O-3841 and THL respectively).