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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Shock. 2008 Sep;30(3):329–335. doi: 10.1097/SHK.0b013e31816471c6

Fig. 1. Time course of the effects of 5,14-HEDGE (the synthetic 20-HETE mimetic) and 20-HEDE (the competitive antagonist of vasoconstrictor effects of 20-HETE) on (A) MAP and (B) HR after administration of saline (vehicle) (4 mL/kg, i.p.) or endotoxin (10 mg/kg, i.p.) to conscious rats.

Fig. 1

5,14-HEDGE (30 mg/kg, s.c.) or 20-HEDE (30 mg/kg, s.c.) was given 1 h after administration of endotoxin. Mean values ± SEM are presented. Numbers in parentheses indicate the number of animals studied per group. a indicates a significant difference from the corresponding value seen in rats treated with saline (vehicle) (P < 0.05). b indicates a significant difference from the corresponding value seen in the rats treated with vehicle and endotoxin (P < 0.05). c indicates a significant difference from the corresponding value seen in the rats treated with vehicle and 5,14-HEDGE (P < 0.05). d indicates a significant difference from the corresponding value seen in the rats treated with endotoxin and 5,14-HEDGE (P < 0.05). e indicates a significant difference from the corresponding value seen in the rats treated with vehicle and 20-HEDE (P < 0.05). f indicates a significant difference from the time 0 value within a group (P < 0.05). g indicates a significant difference from the time 1 value in each group (P < 0.05).