. 2008 Aug 13;64(Pt 9):977–984. doi: 10.1107/S0907444908022348

Table 1. Enzyme inhibition (IC₅₀ in nM) against DHFR for selected inhibitors (Fig. 1 ▶; Chan et al., 2005 ▶; Rosowsky et al., 2004 ▶).

Inhibitor	pcDHFR	Rat DHFR	Rat DHFR/pcDHFR selectivity ratio
TMP	13000	180000	13.8
PTX	13	3.3	0.26
PT684	1.1	1500	1363
PT682	1.0	580	580
PT684a	31	14	1.3
PT653	79	3000	37.9

Table 1. Enzyme inhibition (IC50 in nM) against DHFR for selected inhibitors (Fig. 1 ▶; Chan et al., 2005 ▶; Rosowsky et al., 2004 ▶).