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Differentiation of Th17 cells is supported by TGF-β, IL-6, TNF and IL-1 while IL-23 is required for their expansion and survival. Th17 cells secrete IL-17 and their major function is to enhance neutrophil mobilisation. IL-17 is required for effective immunity against specific bacterial and fungal infections in mice. Th17 cells contribute to autoimmune disease in certain models and can either increase or reduce immunity to cancer.
