TABLE 1.

Genes regulated by the expression of the α6β4 integrin in MDA-MB-435 cells

Gene symbols in boldface type denote genes that are found in more than one category.

Function	Number	Up-regulated	Down-regulated
Motility	36	SFRP1, MARCKS, ENPP2, CAPG, FST, PTPRZ1, PDLIM4, S100A4, ARHGEF3, CHL1, KIF5C, MYH10, CTGF, FSCN1, SEMA3A, PTPN22, ELMO1, NRCAM, EDG2, HMGCR	MYLK, FOS, MAP1B, ADM, IL8, S100A2, EGR1, FGF13, RAC2, LIF, GADD45A, ITGB1BP1, FOSL1, SDC1, Cortactin, CYR61
Apoptosis	56	SFRP1, CRYAB, FST, PEG10, S100A4, MAP2K6, DMD, HDAC4, GPR37, DNAJB6, RAD51C, CHL1, SATB1, QKI, IVNS1ABP, CTGF, TXNIP, TPD52L1, SEMA3A, SGCD, NRCAM, PRKD1, HELLS, EDG2, CFDP1, PTGER4	BCL2A1, CSNK1E, GADD45B, CCND1, RIPK2, SPP1, BCL6, FOS, MYLK, TGFBI, TNFAIP3, MAP1B, ADM, IL8, FN1, EGR1, MMP1, THBS1, RAC2, LIF, GADD45A, FOSL1, CARD10, NGFRAP1, IGFBP7, DKK1, UCP2, CEBPD, CYR61, IL7R
Transcription regulation	10	SOX4, NKX2-2, HDAC4, TCFL5, CSRP2, TRIM9, MEF2C	FOS, FOSL1, CEBPD
Extracellular matrix, cell adhesion, cytoskeleton	32	CHRDL1, SPARCL1, DSG2, COL9A3, DMD, HAPLN1, HS3ST3A1, TUBB6, COL6A2, CHL1, ANK2, COL1A2, CALD1, FSCN1, TUBB4, ITGA10, NRCAM, COL5A2, CDH19	MUC1, TNC, EVL, MCAM, FN1, THBS1, RAC2, TUBA1, SDC1, CDC42EP1, MYL9, COL13A1, CYR61
Proteases, inhibitors	9	ADAMTS1, PRSS11, MMP14, CAPN3, CTSB	MMP1, PRSS7, SERPINB1, SERPINA3
Metabolism	29	TYRP1, MAOA, BCHE, DCT, ENO2, AKR1C1, AKR1C2, AKR1C3, ASPA, GALNT11, ALDH1A1, TDG, EPHX1, LOXL2, AGPAT5, TNKS, CA8, NMT2, MRPS6, SLC5A3, ATP5I, MTUS1	ASNS, KYNU, PDE2A, GLUL, GSTT2, WARS, NNMT
Other signaling molecules	17	PHACTR1, EPHA3, PRKCBP1, PTPLA, BMP1, FZD7, SKP2	AKAP2, SHB, RAB27A, PPM2C, IL1RAP, KCNS3, KDELR3, DUSP5, P2RX5, KCTD14
Antigen presentation	8		HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB4
Protein stability	8	CRYAB, DNAJB6, DNAJC12, USP9X, HSPA1A	UBE2H, SMURF2, TMAP1