TABLE 2.

Effect of vesicle size and composition on the C₅₀ values of PZA and BAR-PZA C50 values were determined as described previously (26). DSPC indicates LUVs containing 55% DSPC, 20% PE, 15% PS, 7.5% PI, and 2.5% PIP₂. Egg PC indicates LUVs containing 55% egg PC, 20% PE, 15% PS, 7.5% PI, and 2.5% PIP₂. 1 μm indicates LUVs were extruded through a filter with a 1-μm pore; 0.1 μm indicates extrusion through filters with a 0.1-μm pore. The results are the means ± S.E. of three experiments.

Enzyme	C50
	DSPC, 1 μm	DSPC, 0.1 μm	Egg PC, 1 μm	Egg PC, 0.1 μm
	nm
PZA	0.017 ± 0.005	0.031 ± 0.004	0.076 ± 0.014	0.075 ± 0.016
BAR-PZA	1.00 ± 0.37	1.24 ± 0.05	0.90 ± 0.17	0.89 ± 0.09