TABLE 1.

Percent identity of C2 domains across vertebrates

Amino acid sequences from vertebrate classes were analyzed to identify the C2 domains using the Simple Modular Architecture Research Tool (SMART; EMBL, Heidelberg, Germany). The predicted C2 domains were aligned against the corresponding predicted mouse C2 domains. The amino acid identity for each was determined by the BLAST program (NCBI, Bethesda, MD). The percent identity of each C2 domain is referenced to the corresponding mouse sequence. GenBank™ accession numbers (protein) are listed in parentheses.

Species	C2A	C2B	C2C	C2D	C2E	C2F
Human (34/40331)	90	100	100	100	97	98
Rat (149050818)	94	100	100	99	100	100
Chick (118089149)	75	93	89	90	94	94
Zebrafish (113462015)	74	90	89	83	93	93
Tetraodon (47224638)	70	90	91	52	92	90