FIGURE 8.

Architecture of the AP-3-HPS protein interaction network. A describes the subunit composition of the AP-3, BLOC-1, BLOC-2, and HOPS complexes depicted in B. Subunits highlighted in red are those identified in this study by immunoblot and/or MS/MS. B, proposed diagram of interactions among components identified. Proteins pairs linked by lines highlighted with a single asterisk indicate interactions curated in BioGRID. Double asterisks denote interactions documented here and by others (16, 40). Annx II, annexin II; HC, heavy chain; LC, light chain.