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. 2009 Jan 16;284(3):1644–1651. doi: 10.1074/jbc.M807888200

FIGURE 4.

FIGURE 4.

Mediators of IFN-β induction by transfected PsiRNA and pIpC. A, IFN-β induction following the knockdown of IPS-1 in parental HeLa cells (PKR+) and PKR stable knockdown HeLa cells (PKRkd). B, IFN-β induction in parental HeLa cells treated with CsiRNAs to transiently knockdown PKR, IRF3, and TRIF. The cells were transfected with CsiLUC20, PsiLUC50, or pIpC and IFN-β transcript levels were determined by real time PCR at 5 h post-transfection. For A and B, the mean inductions of IFN-β mRNA and standard deviations from four independent experiments are shown. **, p < 0.01. C, representative Western blot showing the knockdown of IPS-1, PKR, IRF3, and TRIF in parental and PKRkd HeLa cells.