Table 1.
Potential molecular targets for luteolin's anticancer activity*
| Luteolin's effects | Processes involved in carcinogenesis | |||||
|---|---|---|---|---|---|---|
| Carcinogen Activation | Cell proliferation | Cell survival signaling | Apoptosis | Angiogenesis | Metastasis | |
| p27/kip1 | DR5 | |||||
| p21/waf1 | Caspases | |||||
| Activation | p53 | Fas | ||||
| Bax | ||||||
| p53 | ||||||
| |
|
|
|
JNK |
|
|
| CYP1A1 | NFκB | IGF-IR | DNA topoisomerases | VEGF | TNFα | |
| CYP1A2 | MAPKs | PDGF | XIAP | VEGFR | IL-6 | |
| CYP1B1 | PI3K/Akt | PI3k/Akt | Bcl-XL | MMP-9 | MMP-1 | |
| CDK2 | EGFR | Fatty acid synthase | NF-κB | FAK | ||
| Inhibition | ER | HIF-1α | Twist | |||
| PKC | Hyaluronidase | NF-κB | ||||
| NF-κB | PI3k/Akt | PI3k/Akt | ||||
| MAPKs | ERK | |||||
*
Some factors are involved in multiple processes. For details please refer the papers cited in the text.