Table 1 .
Drug categories (from ICD external cause codes) responsible for admission for first time adverse drug reaction (ADR) in patients aged ≥60, Western Australia, 1980-2000
| Drug category (as defined in ICD-10-AM) | ICD-9/ICD-9-CM | ICD-10-AM | No (%) of patients |
|---|---|---|---|
| Systemic antibiotics* | E930 | Y40 | 2672 (9.4) |
| Other systemic anti-infectives/antiparasitics | E931 | Y41 | 430 (1.5) |
| Hormones (including synthetics and antagonists) | E932 | Y42 | 2174 (7.6) |
| Primarily systemic agents | E933 | Y43 | 2122 (7.4) |
| Agents primarily affecting blood constituents | E934 | Y44 | 2432 (8.5) |
| Analgesics/antipyretics/anti-inflammatory drugs | E935 | Y45 | 4694 (16.4) |
| Antiepileptics/antiparkinsonian drugs | E936 | Y46 | 1121 (3.9) |
| Sedatives, hypnotics, antianxiety drugs | E937 | Y47 | 406 (1.4) |
| Anaesthetics and therapeutic gases | E938 | Y48 | 414 (1.5) |
| Psychotropic drugs† | E939 | Y49 | 1534 (5.4) |
| Central nervous system stimulants | E940 | Y50 | 18 (0.1) |
| Drugs primarily affecting autonomic nervous system‡ | E941 | Y51 | 476 (1.7) |
| Agents primarily affecting cardiovascular system | E942 | Y52 | 5576 (19.5) |
| Agents primarily affecting gastrointestinal system | E943 | Y53 | 252 (0.9) |
| Agents affecting water balance/minerals/uric acid§ | E944 | Y54 | 2024 (7.1) |
| Agents affecting muscles/respiratory system | E945 | Y55 | 563 (2.0) |
| Topical agents affecting skin, eyes, ENT, dental | E946 | Y56 | 577 (2.0) |
| Other and unspecified drugs and medicines | E947 | Y57 | 982 (3.4) |
| Bacterial vaccines | E948 | Y58 | 16 (0.1) |
| Other and unspecified vaccines/biologicals | E949 | Y59 | 65 (0.2) |
| Total | 28 548 (100.0) |
ADR=adverse drug reaction; ICD=International Classification of Diseases; ENT=ear, nose, throat.
*Excludes antineoplastic antibiotics (E930.7) from ICD-9/ICD-9-CM (were added to primarily systemic agents, which include antineoplastics).
†Excludes benzodiazepines (E939.4) from ICD-9/ICD-9-CM (were added to group sedatives, hypnotics, antianxiety drugs, which includes benzodiazepines in ICD-10).
‡Excludes sympatholytics (E941.3) from ICD-9/ICD-9-CM (were added to agents primarily affecting cardiovascular system, which include these in ICD-10).
§Excludes theophylline (E944.1) from ICD-9/ICD-9-CM (was added to agents affecting muscles/respiratory system, which includes antiasthmatics).