Table 2 .
Top 30 drug groups (ICD E codes) most often implicated in admission for first time adverse drug reaction (ADR) in 28 548 patients aged ≥60, Western Australia, 1980-2000
| Drug groups (as defined in ICD-10-AM) | ICD-9/ICD-9-CM | ICD-10-AM | No (%) of patients |
|---|---|---|---|
| Systemic antibiotics: | |||
| Penicillins | E930.0 | Y40.0 | 881 (3.1) |
| Unspecified systemic antibiotics | E930.9 | Y40.9 | 569 (2.0) |
| Other systemic antibiotics | E930.8 | Y40.8 | 505 (1.8) |
| Cephalosporins and other β lactams | E930.5 | Y40.1 | 353 (1.2) |
| Hormones (including synthetics and antagonists): | |||
| Glucocorticoids and synthetics | E932.0 | Y42.0 | 1328 (4.7) |
| Insulins and oral antidiabetic drugs | E932.3 | Y42.3 | 416 (1.5) |
| Primarily systemic agents: | |||
| Antineoplastic/immunosuppressive drugs | E933.1/E930.7 | Y43.1-4 | 1980 (6.9) |
| Agents primarily affecting blood constituents: | |||
| Anticoagulants | E934.2 | Y44.2 | 1964 (6.9) |
| Thrombolytic drugs | E934.4 | Y44.5 | 247 (0.9) |
| Analgesics/antipyretics/anti-inflammatory drugs: | |||
| NSAIDs and antirheumatics | E935.6 | Y45.2-4 | 2026 (7.1) |
| Opioids and related analgesics | E935.2 | Y45.0 | 1388 (4.9) |
| Salicylates | E935.3 | Y45.1 | 442 (1.5) |
| 4-aminophenol derivatives (such as paracetamol) | E935.4 | Y45.5 | 361 (1.3) |
| Antiepileptics and antiparkinsonian drugs: | |||
| Hydantoin derivatives | E936.1 | Y46.2 | 408 (1.4) |
| Antiparkinsonian drugs | E936.4 | Y46.7 | 359 (1.3) |
| Other and unspecified antiepileptics | E936.3 | Y46.6 | 302 (1.1) |
| Psychotropic drugs: | |||
| Antidepressants | E939.0 | Y49.0-2 | 596 (2.1) |
| Phenothiazine antipsychotics/neuroleptics | E939.1 | Y49.3 | 365 (1.3) |
| Agents primarily affecting cardiovascular system: | |||
| Cardiac stimulant glycosides/similar drugs | E942.1 | Y52.0 | 1702 (6.0) |
| Other antihypertensive drugs | E942.6 | Y52.5 | 1708 (6.0) |
| Other antidysrhythmic drugs | E942.0 | Y52.2 | 786 (2.8) |
| Coronary vasodilators | E942.4 | Y52.3 | 662 (2.3) |
| Peripheral vasodilators (ICD-9 sympatholytics) | E941.3 | Y52.7 | 269 (0.9) |
| Agents affecting water balance, mineral/uric acid metabolism: | |||
| Loop and other diuretics | E944.4 | Y54.4-5 | 1257 (4.4) |
| Benzothiadiazine derivatives | E944.3 | Y54.3 | 322 (1.1) |
| Uric acid metabolism drugs (such as colchicine) | E944.7 | Y54.8 | 242 (0.8) |
| Agents affecting muscles/respiratory system: | |||
| Antiasthmatics (including theophylline) | E944.1/E945.7 | Y55.6 | 472 (1.7) |
| Topical agents affecting skin, eyes, ENT, dental: | |||
| Local anti-infectives/anti-inflammatory drugs | E946.0 | Y56.0 | 435 (1.5) |
| Other and unspecified drugs and medicines: | |||
| Unspecified drug or medicines | E947.9 | Y57.9 | 555 (1.9) |
| Other drugs or medicines | E947.8 | Y57.8 | 354 (1.2) |
| Total | 23 254 (81.5) | ||
ADR=adverse drug reaction; ICD=International Classification of Diseases; NSAIDs=non-steroidal anti-inflammatory drugs; ENT=ear, nose, throat.