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Mechanism of Action of DP. DP increases local concentrations of adenosine, which stimulates adenylyl cyclase in platelets leading to increased intracellular cAMP levels. In addition, by inhibiting PDE, DP prevents the breakdown of cAMP. Increased intracellular levels of cAMP keep platelets from being activated. Furthermore, by inhibiting PDE in the vascular wall, DP increases PGI2 production and vascular smooth muscle cGMP levels, leading to vasodilation.
