Table 3.
Patient characteristics categorized by MDM2 protein expression
| AA | CA | |||||||
|---|---|---|---|---|---|---|---|---|
| Patient characteristics | Total AA No. (%) | ≤10% No. (%) | >10% No. (%) | P value* | Total CA No. (%) | ≤10% No. (%) | >10% No. (%) | P value |
| No. of patients | 51(100) | 28(54.9) | 23(45.1) | - | 50(100) | 11(22. 0) | 39(78.0) | - |
| SNP300 genotype | ||||||||
| TT | 35(100) | 22(62.9) | 13(37.1) | 0.09 | 31(100) | 7(22.6) | 24(77.4) | 0.9 |
| TG or GG | 16(100) | 6(37.5) | 10(62.5) | 19(100) | 4(21.1) | 15(78.9) | ||
| Age at diagnosis | ||||||||
| <60 yr | 14(100) | 6(42.9) | 8(57.1) | 0.29 | 15(100) | 3(20) | 12(80.0) | 0.82 |
| >60 yr | 37(100) | 22(59.5) | 15(40.5) | 35(100) | 8(22.9) | 27(77.1) | ||
| Pathologic stage | ||||||||
| pTl/T2 | 29(100) | 16(55.2) | 13(44.8) | 0.96 | 30(100) | 7(23.3) | 23(76.7) | 0.78 |
| pT3/T4 | 22(100) | 12(54.5) | 10(45.5) | 20(100) | 4(20.0) | 16(80.0) | ||
| PSA | ||||||||
| ≤10 | 28(100)** | 14(50.0) | 14(50.0) | 0.52 | 35(100)** | 6(17.1) | 23(76.7) | 0.78 |
| >10 | 22(100) | 13(59.1) | 9(40.9) | 10(100) | 4(20.0) | 16(80.0) | ||
| Gleason grade | ||||||||
| <7 | 24(100) | 11(45.8) | 13(54.2) | 0.22 | 29(100) | 6(20.7) | 23(79.3) | 0.79 |
| ≥7 | 27(100) | 17(63.0) | 10(37.0) | 21(100) | 5(23.8) | 16(76.2) | ||
| Recurrence | 18(100) | 10(55.6) | 8(44.4) | 0.63 | 11(100) | 2(18.2) | 9(81.8) | 0.86 |
*
Chi-square or Fisher’s exact test as appropriate
**
One AA and 5 CA patients missing from this analysis