Table 1.
List of 68 enrichment tools
| Enrichment tool name | Year of release | Key statistical method | Category |
|---|---|---|---|
| FunSpec | 2002 | Hypergeometric | Class I |
| Onto-express | 2002 | Fisher's exact; hypergeometic; binomial; chi-square | Class I |
| EASE | 2003 | Fisher's exact (modified as EASE score) | Class I |
| FatiGO/FatiWise/FatiGO+ | 2003 | Fisher's exact | Class I |
| FuncAssociate | 2003 | Fisher's exact | Class I |
| GARBAN | 2003 | Hypergeometric | Class I |
| GeneMerge | 2003 | Hypergeometric | Class I |
| GoMiner | 2003 | Fisher's exact | Class I |
| MAPPFinder | 2003 | Z-score; hypergeometric | Class I |
| CLENCH | 2004 | Hypergeometric; chi-square; binomial | Class I |
| GO::TermFinder | 2004 | hypergeometric | Class I |
| GOAL | 2004 | Permutation | Class I |
| GOArray | 2004 | Hypergeometric; Z-score; permutation | Class I |
| GOStat | 2004 | Fisher's exact; chi-squre | Class I |
| GoSurfer | 2004 | Chi-square | Class I |
| OntologyTraverser | 2004 | Hypergeometric; Fisher's exact | Class I |
| THEA | 2004 | Hypergeometric | Class I |
| BiNGO | 2005 | Hypergeometric; binomial | Class I |
| FACT | 2005 | Adopt GeneMerge and GO::TermFinder statistical modules | Class I |
| gfinder | 2005 | Fisher's exact | Class I |
| Gobar | 2005 | Hypergeometric | Class I |
| GOCluster | 2005 | Hypergeometric | Class I |
| GOSSIP | 2005 | Fisher's exact | Class I |
| L2L | 2005 | Binomial; hypergeometric | Class I |
| WebGestalt | 2005 | Hypergeometric | Class I |
| BayGO | 2006 | Bayesian; Goodman and Kruskal's gamma factor | Class I |
| eGOn/GeneTools | 2006 | Fisher's exact | Class I |
| Gene Class Expression | 2006 | Z-statistics | Class I |
| GOALIE | 2006 | Hidden Kripke model | Class I |
| GOFFA | 2006 | Fisher's inverse chi-square | Class I |
| GOLEM | 2006 | Hyerpgeometric | Class I |
| JProGO | 2006 | Fisher's exact; Kolmogorov–Smirnov test; student's t-test; Wilcoxon's test; hypergeometric | Class I |
| PageMan | 2006 | Fisher's exact; chi-square; Wilcoxon | Class I |
| STEM | 2006 | Hypergeometric | Class I |
| WEGO | 2006 | Chi-square | Class I |
| EasyGO | 2007 | Hypergeometric; chi-square; binomial | Class I |
| g:Profiler | 2007 | Hypergeometric | Class I |
| ProbCD | 2007 | Yule's Q; Goodman-Kruskal's gamma; Cramer's T | Class I |
| GOEAST | 2008 | Hypergeometric | Class I |
| GOHyperGAll | 2008 | Hypergeometric | Class I |
| CatMap | 2004 | Permutations | Class II |
| Godist | 2004 | Kolmogorov–Smirnov test | Class II |
| GO-Mapper | 2004 | Gaussian distribution; EQ-score | Class II |
| iGA | 2004 | Permutations; hypergeometric; t-test; Z-score | Class II |
| GSEA | 2005 | Kolmogorov–Smirnov-like statistic | Class II |
| MEGO | 2005 | Z-score | Class II |
| PAGE | 2005 | Z-score | Class II |
| T-profiler | 2005 | t-Test | Class II |
| FuncCluster | 2006 | Fisher's exact | Class II |
| FatiScan | 2007 | Fisher's Exact | Class II |
| FINA | 2007 | Fisher's exact | Class II |
| GAzer | 2007 | Z-statistics; permutation | Class II |
| GeneTrail | 2007 | Hypergeometric; Kolmogorov–Smirnov | Class II |
| MetaGP | 2007 | Z-score | Class II |
| Ontologizer | 2004 | Fisher's exact | Class III |
| POSOC | 2004 | POSET (a discrete math: finite partially ordered set) | Class III |
| topGO | 2006 | Fisher's exact | Class III |
| GO-2D | 2007 | Hypergeometric; binomial | Class III |
| GENECODIS | 2007 | Hypergeometric; chi-square | Class III |
| GOSim | 2007 | Resnik's similarity | Class III |
| PalS | 2008 | Percent | Class III |
| ProfCom | 2008 | Greedy heuristics | Class III |
| GOTM | 2004 | Hypergeometric | Class I,II |
| ermineJ | 2005 | Permutations; Wilcoxon rank-sum test | Class I,II |
| DAVID | 2003 | Fisher's Exact (modified as EASE score) | Class I,III |
| GOToolBox | 2004 | Hypergeometric; Fisher's exact; Binomial | Class I,III |
| ADGO | 2006 | Z-statistic | Class II,III |
| FunNet | 2008 | Unclear | Unclear |