Table 2.
Pharmacokinetic characteristics of iothalamatea
| Pharmacokinetic Parameter | Median | Q1 | Q3 |
|---|---|---|---|
| Plasma iothalamate clearance (ml/min) | 47.8 | 33.9 | 65.6 |
| Plasma iothalamate clearance (ml/min/1.73m2) | 37.7 | 30.1 | 50.6 |
| Volume of distribution central (ml) | 4797 | 2275 | 6266 |
| Volume of distribution (ml/kg) | 50.1 | 20.0 | 67.4 |
| Volume of distribution, steady state (ml) | 15908 | 13822 | 18827 |
| Volume of distribution, steady state (ml/kg) | 172.4 | 147.1 | 190.6 |
| Elimination half-life (min) | 66 | 24 | 115 |
| Area under curve (μg × min/ml) | 62856 | 45847 | 89286 |
| Fast component | |||
| intercept A (μg/ml) | 452 | 320 | 1207 |
| half-life ln(2)/α (min) | 4.83 | 2.39 | 7.18 |
| area A/α (μg·min/ml) | 5335 | 2843 | 3624 |
| Slow component | |||
| intercept B (μg/ml) | 161 | 136 | 183 |
| half-life ln(2)/β (min) | 271 | 199 | 336 |
| area B/β (μg·min/ml) | 57615 | 40924 | 81973 |
a
Q1, first quartile; Q3, third quartile.