Table 6.

Sampling duration and area under the curve (AUC) estimates stratified by eGFR^a

Sampling Duration	Mean AUC (μg · min/ml)	95% CI	Ratio compared to 10-h AUC	95% CI of Ratio	P
eGFR stratum >30 ml/min/1.73m2
10 h	65,427	51,731 to 82,749
9 h	63,968	50,707 to 80,697	0.98	0.88 to 1.09	>0.2
8 h	62,603	49,625 to 78,975	0.96	0.86 to 1.07	>0.2
7 h	60,365	47,851 to 76,151	0.92	0.83 to 1.03	0.15
6 h	58,271	46,191 to 73,510	0.89	0.80 to 0.99	0.037
5 h	55,796	44,229 to 70,388	0.85	0.76 to 0.95	0.004
4 h	53,466	42,382 to 67,449	0.82	073 to 0.91	<0.001
3 h	49,628	39,240 to 62,768	0.76	0.68 to 0.85	<0.001
2.5 h	46,464	36,831 to 58,615	0.71	0.64 to 0.79	<0.001
2 h	42,330	33,555 to 53,400	0.65	0.58 to 0.72	<0.001
eGFR stratum <30 ml/min/1.73m2
10 h	105,432	83,576 to 133,005
9 h	99,198	78,633 to 125,140	0.94	0.85 to 1.04	>0.2
8 h	94,490	74,901 to 119,201	0.90	0.81 to 0.99	0.037
7 h	90,584	71,805 to 114,273	0.86	0.77 to 0.95	0.004
6 h	85,141	67,491 to 107,407	0.81	0.73 to 0.90	<0.001
5 h	77,359	61,322 to 97,590	0.73	0.66 to 0.81	<0.001
4 h	70,104	55,571 to 88,438	0.66	0.60 to 0.74	<0.001
3 h	59,402	46,968 to 75,126	0.56	0.51 to 0.63	<0.001
2.5 h	52,466	41,589 to 66,187	0.50	0.45 to 0.55	<0.001
2 h	46,656	36,984 to 58,857	0.44	0.40 to 0.49	<0.001

^aAUC calculated using a nominal mixed model with maximal likelihood estimates.