Table 2.
Performance characteristics of ultrasonographic diagnostic criteria for type 1 and 2 ADPKD in at-risk individuals between 30 and 59 yr of agea
| Age Group (yr) | Diagnostic Criterion | Disease Subtype | Sensitivity | Specificity | NPV | PPV | Accuracy |
|---|---|---|---|---|---|---|---|
| 30 to 39 | ≥2 cysts in each kidney | PKD1 | 0.933 (0.870 to 0.985) | 1.000 | 0.954 (0.913 to 0.990) | 1.000 | 0.972 (0.946 to 0.994) |
| PKD2 | 0.758 (0.630 to 0.875) | 1.000 | 0.816 (0.719 to 0.908) | 1.000 | 0.883 (0.813 to 0.943) | ||
| ≥1 renal cyst | PKD1 | 1.000 | 0.960 (0.917 to 0.991) | 1.000 | 0.948 (0.894 to 0.988) | 0.977 (0.952 to 0.995) | |
| PKD2 | 0.967 (0.905 to 1.000) | 0.938 (0.862 to 1.000) | 0.968 (0.911 to 1.000) | 0.935 (0.860 to 1.000) | 0.952 (0.906 to 0.990) | ||
| ≥2 renal cystsb | PKD1 | 0.982 (0.948 to 1.000) | 0.987 (0.951 to 1.000) | 0.987 (0.961 to 1.000) | 0.982 (0.943 to 1.000) | 0.985 (0.963 to 1.000) | |
| PKD2 | 0.949 (0.880 to 1.000) | 0.979 (0.930 to 1.000) | 0.954 (0.889 to 1.000) | 0.977 (0.927 to 1.000) | 0.965 (0.925 to 0.991) | ||
| ≥3 renal cystsb | PKD1 | 0.966 (0.914 to 1.000) | 1.000 | 0.976 (0.940 to 1.000) | 1.000 | 0.986 (0.964 to 1.000) | |
| PKD2 | 0.949 (0.882 to 1.000) | 1.000 | 0.954 (0.889 to 1.000) | 1.000 | 0.975 (0.941 to 1.000) | ||
| 40 to 59 | ≥2 cysts in each kidney | PKD1 | 0.926 (0.825 to 1.000) | 1.000 | 0.975 (0.941 to 1.000) | 1.000 | 0.981 (0.955 to 1.000) |
| PKD2 | 0.888 (0.767 to 0.974) | 1.000 | 0.923 (0.846 to 0.982) | 1.000 | 0.952 (0.901 to 0.989) | ||
| ≥1 renal cyst | PKD1 | 1.000 | 0.939 (0.886 to 0.980) | 1.000 | 0.845 (0.718 to 0.947) | 0.954 (0.914 to 0.985) | |
| PKD2 | 1.000 | 0.937 (0.857 to 1.000) | 1.000 | 0.923 (0.829 to 1.000) | 0.964 (0.920 to 1.000) | ||
| ≥2 renal cystsb | PKD1 | 1.000 | 0.984 (0.955 to 1.000) | 1.000 | 0.955 (0.872 to 1.000) | 0.988 (0.965 to 1.000) | |
| PKD2 | 1.000 | 0.978 (0.925 to 1.000) | 1.000 | 0.972 (0.909 to 1.000) | 0.988 (0.958 to 1.000) | ||
| ≥3 renal cystsb | PKD1 | 1.000 | 0.985 (0.955 to 1.000) | 1.000 | 0.957 (0.875 to 1.000) | 0.988 (0.966 to 1.000) | |
| PKD2 | 0.956 (0.872 to 1.000) | 0.978 (0.929 to 1.000) | 0.968 (0.911 to 1.000) | 0.970 (0.900 to 1.000) | 0.969 (0.927 to 1.000) |
a
Data are means (95% CI). Accuracy of each test criterion was derived from 1000 bootstrap samples of the original data. The results in the 40- to 49- and 50- to 59-yr age groups were very similar and are combined into a single group.
b
Unilateral or bilateral.