Table 3.

Side effects reported as moderate or severe by over 5% of participants on Day 10 of either medication period.

Side effect	Participants rating side effect as moderate or severe at Day 10 of:				P
	Varenicline		Placebo
	N	%	N	%
Dry mouth	15	22.4	6	9.0	.035
Abnormal dreams	14	20.9	2	3.0	.004
Increased flatulence	14	20.9	9	13.4	.18
Fatigue	10	14.9	5	7.5	.18
Nausea	10	14.9	1	1.5	.004
Reflux	10	14.9	1	1.5	.004
Sleep disorder	8	11.9	2	3.0	.07
Insomnia	7	10.4	6	9.0	1.00
Abdominal pain	6	9.0	2	3.0	.22
Constipation	6	9.0	0	0.0	.031
Stomach pain	5	7.5	0	0.0	.06
Headache	4	6.0	3	4.5	1.00
Taste problems	4	6.0	2	3.0	.69

Note. P-values are for McNemar tests comparing varenicline to placebo.