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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Gene Ther. 2008 Aug 14;16(1):60–69. doi: 10.1038/gt.2008.137

Figure 4. Influence of gender and proteasome inhibition on scAAV mediated transgene expression.

Figure 4

Human FIX concentration (hFIX) in murine plasma after tail vein administration of 4 × 109 vg/kg of scAAV2/8-LP1-hFIXco in cohorts (n=6) of male (Panel A) and female (Panel B) C57Bl/6 mice. A proportion of these animals were treated with a single dose of bortezomib 24 hours (Grey bar) before or with two doses of bortezomib given 24 hours before and again 24 hours (Clear Bar) after scAAV administration and their hFIX expression compared with mice that received excipient (Crisscross bar) alone. All transgene expression values are depicted as average together with the standard error of the mean.