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Effect of parecoxib on (A) hindpaw edema, (B) hindpaw withdrawal latency and (C) tail-flick latency following intraplantar zymosan administration in the ipsilateral hindpaw and PBS in the contralateral hindpaw. Parecoxib (20 mg/kg, i.p., 30 min prior to the zymosan challenge) or vehicle was administered. Data are presented as means ± SEM (6 mice per group). *p<0.01 compared to vehicle-treated group.
