. Author manuscript; available in PMC: 2010 Feb 1.

Published in final edited form as: Diabetologia. 2008 Dec 4;52(2):318–328. doi: 10.1007/s00125-008-1221-7

Table 2.

Body composition of recipient mice after 12 wks on respective diets

	n	Body Wt (g)	Total Fat (g)	Perigonadal Fat Pad (g)	Perirenal Fat Pad (g)	Subscapular Fat Pad (g)
LF Diet
MθTLR4+/+	8	25 ± 1	6.3 ± 0.6	0.81 ± 0.10	0.31 ± 0.04	0.07 ± 0.01
MθTLR4-/-	6	22 ± 1	4.3 ± 0.8	0.52 ± 0.08	0.23 ± 0.07	0.06 ± 0.01
HF Diet
MθTLR4+/+	8	26 ± 1	8.1 ± 1.3^*	1.01 ± 0.17^**	0.50 ± 0.11^*	0.08 ± 0.01
MθTLR4-/-	5	29 ± 1	9.7 ± 0.6^*	1.30 ± 0.08^**	0.66 ± 0.20^*	0.09 ± 0.01
HF^SFA Diet
MθTLR4+/+	10	26 ± 1	8.7 ± 0.9^**	1.04 ± 0.10^*	0.59 ± 0.07^*	0.10 ± 0.01
MθTLR4-/-	6	28 ± 1	9.9 ± 0.5^**	1.15 ± 0.08^*	0.57 ± 0.06^*	0.09 ± 0.02
HF^SFA+FO Diet
MθTLR4+/+	9	31 ± 1^‡‡	12.3 ± 0.9^‡‡	1.61 ± 0.12^‡‡‡	0.79 ± 0.09^***	0.14 ± 0.02^‡
MθTLR4-/-	6	32 ± 1^‡‡	13.3 ± 1.2^‡‡	1.74 ± 0.12^‡‡‡	0.81 ± 0.06^***	0.13 ± 0.01^‡

Data are mean ± SEM from 5-11 mice per group. Body composition was measured after mice were fed their respective diets for 12 wks. Student’s t-test revealed there were no significant differences between MθTLR4+/+ and MθTLR4-/-mice. Two-way ANOVA revealed a main effect for diets for all weights listed (P<0.00001). There were no significant main effects for macrophage TLR4 genotype. Significant findings of post-hoc tests as indicated.

P<0.05 for diet compared to LF

^**

P<0.005 for diet compared to LF

^***

P<0.0001 for diet compared to LF

^‡

P<0.05 for diet compared to all other diets

^‡‡

P<0.005 for diet compared to all other diets

^‡‡‡

P<0.0005 for diet compared to all other diets