Table 1.

Incidence of adverse events in antimalarial prophylaxis arms according to severity. Values are numbers (percentages, 95% confidence intervals) unless stated otherwise.

Type of adverse event	Mefloquine group* (n=153)	Chloroquine and proguanil group (n=153)	Doxycycline group (n=153)	Atovaquone and proguanil (n=164)	P value
Severity of adverse event:
Mild†	135 (88, 83 to 93)	131 (86, 80 to 91)	128 (84, 78 to 90)	134 (82, 75 to 88)	0.42
Moderate‡	64 (42, 34 to 50)	69 (45, 37 to 53)	51 (33, 26 to 41)	53 (32, 25 to 40)	0.048
Severe§	16 (11, 6 to 15)	19 (12, 7 to 18)	9 (6, 2 to 10)	11 (7, 2 to 11)	0.14
Withdrawals	6 (4, 1 to 8)	8 (5, 2 to 9)	5 (3, 0 to 6)	3 (2, 0 to 4)	0.42

^*One participant had a transient ischaemic attack outside follow up; history of two episodes was not declared (mefloquine serum concentrations were negligible).

^†Trivial but some discomfort noted.

^‡Interferes with daily activity.

^§Medical advice required.