Table 2.

Proportion of participants in each antimalarial prophylaxis arm reporting adverse events, by type and severity, Values are numbers (percentages, 95% confidence intervals) unless stated otherwise

Type of adverse event	Mefloquine group (n=153)	Chloroquine and proguanil group (n=153)	Doxycycline group (n=153)	Atovaquone and proguanil group (n=164)	P value
Neuropsychological*:
Severe	8 (5, 2 to 9)	6 (4, 1 to 7)	1 (1, 0 to 2)	5 (3, 0 to 6)	0.139
Moderate	56 (37, 29 to 44)	46 (30, 23 to 37)	36 (24, 17 to 30)	32 (20, 13 to 26)	0.003
All events	118 (77, 70 to 84)	107 (70, 63 to 77)	105 (69, 61 to 76)	109 (67, 60 to 74)	0.187
Gastrointestinal†
Severe	6 (4, 1 to 7)	9 (6, 2 to 10)	3 (2, 0 to 4)	5 (3, 0 to 6)	0.312
Moderate	24 (16, 10 to 22)	31 (20, 14 to 27)	14 (9, 5 to 14)	26 (16, 10 to 22)	0.058
All events	89 (58, 50 to 66)	93 (61, 53 to 69)	81 (53, 45 to 61)	88 (54, 46 to 61)	0.451
Skin‡
Severe	1 (1, 0 to 2)	2 (1, 0 to 3)	3 (2, 0 to 4)	1 (1, 0 to 2)	0.635
Moderate	2 (1, 0 to 3)	12 (8, 4 to 12)	5 (3, 1 to 6)	4 (2, 0 to 5)	0.013
All events	36 (24, 17 to 30)	40 (26, 19 to 33)	36 (24, 17 to 30)	34 (21, 15 to 27)	0.730
Skin and vaginal§
Severe	2 (1, 0 to 3)	2 (1, 0 to 3)	4 (3, 0 to 5)	1 (1, 0 to 2)	0.509
Moderate	5 (3, 1 to 6)	13 (9, 4 to 13)	9 (6, 2 to 10)	4 (2, 0 to 5)	0.058
All events	45 (29, 22 to 37)	45 (29, 22 to 37)	42 (28, 20 to 35)	40 (24, 18 to 31)	0.717
Other:
Severe	3 (2, 0 to 4)	5 (3, 0 to 6)	4 (3, 0 to 5)	2 (1, 0 to 3)	0.644
Moderate	12 (8, 4 to 12)	16 (11, 6 to 15)	12 (8, 4 to 12)	12 (7, 3 to 11)	0.748
All events	46 (30, 23 to 37)	47 (31, 23 to 38)	48 (31, 24 to 39)	36 (22, 16 to 28)	0.201

^*Symptoms include headache, strange or vivid dreams, dizziness, anxiety, depression, sleeplessness, and visual disturbance.

^†Nausea, diarrhoea, mouth ulcers.

^‡Itching, abnormal reddening of skin.

^§Itching, abnormal discharge.