Fig. 4.

Visualizing data in DataRail by exploiting data in transformed arrays. A. Structure of the compendium used to generate this plot and the relationship of each feature to data in a transformed array. This structural map was generated using routines internal to DataRail. B. Time courses for the phosphorylation of 17 key proteins (rows) in primary hepatocytes under 11 different conditions of cytokine stimulation (columns) and treated with 7 different small molecule drugs (subpanels within each cytokine-signal block). Curves are colored according to their dynamics (green=sustained, yellow=transient, magenta=late activation, grey=no significant signal). The intensity of the signal determines the intensity of the color. The corresponding signals from HepG2 tumor cells are plotted behind without color coding. The background is blue if the mean signal is stronger for primary cells and red if it is stronger for HepG2 cells; larger differences lead to stronger coloring. In addition, the levels of IL8 at 24 hr, a measure of cellular response, are added as a heat map.