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. Author manuscript; available in PMC: 2009 Jan 12.
Published in final edited form as: Endocrinology. 2006 Nov 16;148(3):1396–1402. doi: 10.1210/en.2006-1109

FIG. 4.

FIG. 4

Effect of VDR level on the relationship between intestinal calcium absorption and plasma 1,25(OH)2 D3 levels. Ninety-day-old mice were fed diets containing different levels of calcium (0.5% Ca, 0.02% Ca, or 2.0% Ca) for a 7-d period before the experiment to modulate plasma levels of 1,25(OH)2 D3 in the mice (n = 8-11/diet group). Gender was balanced across genotype and diet groups and used as a covariate to correct for the higher efficiency of calcium absorption previously seen in female mice (35). Calcium absorption values and plasma 1,25(OH)2 D3 data for individual mice was plotted and regression analysis was conducted. Covariate corrected regression lines are presented by solid (WT) or dashed (HT) lines. WT calcium absorption = 0.31 * 1,25(OH)2 D2 - 11.2 (r2 = 0.85); HT calcium absorption = 0.19 * 1,25(OH)2 D2 - 2.3 (r2 = 0.77, WT vs. HT slope, P < 0.01).