Table 4.
Description of salivary secreted polypeptides deposited in GenBank, with summary of proteomic experiments
| Seq name | GenBank accession number and link to NCBI | Status | Description | Match to 1D gel Edman (Fig. 7) | Match to 2D gel MS/MS results (Fig. 8) | Match to 1D PAGE HPLC MS/MS results (Fig. 9) |
|---|---|---|---|---|---|---|
|
Lipocalin family
| ||||||
| OC-15 | 172051078 | Complete | Salivary lipocalin | Y | Y | Y |
| OC-43 | 172051154 | Complete | Salivary lipocalin | Y | ||
| OC-41 | 172051146 | Complete | Salivary lipocalin | Y | ||
| OC-2 | 172051090 | Complete | Salivary lipocalin | Y | Y | |
| OC-3 | 172051116 | Complete | Salivary lipocalin | Y | Y | |
| OC-62 | 172051210 | Complete | Salivary lipocalin | Y | ||
| OC-80 | 172051236 | Complete | Salivary lipocalin | Y | ||
| OC-169 | 172051084 | Complete | Moubatin-like lipocalin | Y | ||
| OC-677 | 172051218 | Complete | Salivary lipocalin | |||
| OC-477 | 172051166 | Complete | Salivary secreted lipocalin | Y | ||
| OC-6 | 172051204 | Complete | Salivary lipocalin | Y | Y | |
| OC-7 | 172051222 | Truncated | Salivary lipocalin | Y | Y | |
| OC-8 | 172051234 | Complete | Salivary lipocalin | Y | ||
| OC-29 | 172051114 | Complete | Salivary lipocalin | Y | Y | |
| OC-28 | 172051112 | Complete | Salivary lipocalin | Y | Y | |
| OC-60 | 172051206 | Complete | Moubatin-like lipocalin | Y | ||
| OC-481 | 172051168 | Complete | Salivary lipocalin | Y | ||
| OC-128 | 172051062 | Complete | Salivary lipocalin | Y | ||
|
Single-Kunitz protease inhibitors | ||||||
| OC-51 | 172051178 | Complete | Savignygrin-like | |||
| OC-52 | 172051182 | Complete | Savignygrin-like RGD containing salivary peptide | |||
| OC-53 | 172051186 | Complete | Savignygrin-like peptide | |||
|
Dual-Kunitz protease inhibitors | ||||||
| OC-24 | 172051102 | Complete | Dual-Kunitz salivary protein | Y | ||
| OC-25 | 172051106 | Complete | Dual-Kunitz salivary protein | Y | ||
| OC-26 | 172051110 | Complete | Dual-Kunitz salivary protein | Y | ||
|
Cystatin | ||||||
| OC-38 | 172051140 | Complete | Salivary cystatin | Y | ||
| OC-37 | 172051136 | Complete | Salivary cystatin 2 | Y | ||
|
Calcitonin/adrenomedulin family peptide | ||||||
| OC-39 | 172051142 | Complete | Calcitonin-related polypeptide | |||
| OC-40 | 172051144 | Complete | Similar to calcitonin/calcitonin-related polypeptide | |||
| OC-49 | 172051174 | Complete | Calcitonin/calcitonin-related polypeptide | |||
| OC-50 | 172051176 | Complete | Calcitonin/calcitonin-related polypeptide | |||
|
Possible mucin | ||||||
| OC-57 | 172051196 | Complete | Salivary mucin | Y | ||
|
Antimicrobial-hebraein family | ||||||
| OC-32 | 172051122 | Truncated | Microplusin-like antimicrobial | |||
| OC-31 | 172051120 | Complete | Hebraein-like | |||
| OC-33 | 172051124 | Complete | Hebraein-like | |||
| OC-696 | 172051220 | Complete | Hebraein-like | |||
|
Defensin | ||||||
| OC-487 | 172051172 | Truncated | Defensin | |||
|
TIL domain-containing peptides | ||||||
| OC-1000 | 172051048 | Complete | Ixodidin | |||
| OC-86 | 172051240 | Complete | Hypothetical conserved secreted protein | |||
|
Salivary enzymes with possible blood-feeding function | ||||||
|
Metalloproteases | ||||||
| OC-372 | 172051138 | Truncated | Metalloprotease | Y | ||
| OC-676 | 172051216 | Truncated | Salivary metalloprotease | |||
|
Phospholipase A2 fragments | ||||||
| OC-420 | 172051150 | Truncated | Phospholipase A2 | |||
| OC-92 | 172051246 | Truncated | Phospholipase A2 | Y | ||
| OC-96 | 172051250 | Truncated | Phospholipase A2 | Y | ||
|
5′-nucleotidase/apyrase precursor fragment | ||||||
| OC-79 | 172051232 | Truncated | 5′-nucleotidase/putative apyrase precursor | Y | ||
|
Tick families of unknown function | ||||||
|
Basic tail family | ||||||
| OC-21 | 172051094 | Complete | BTSP | Y | Y | |
| OC-20 | 172051092 | Complete | BTSP | Y | Y | |
| OC-22 | 172051096 | Complete | BTSP | Y | ||
| OC-54 | 172051188 | Complete | Acid tail salivary protein | Y | ||
| OC-56 | 172051192 | Complete | Acid tail salivary protein | Y | ||
| OC-84 | 172051238 | Truncated | BTSP | |||
| OC-139 | 172051076 | Complete | Salivary secreted basic tail protein | |||
| OC-23 | 172051098 | Complete | BTSP | |||
| OC-517 | 172051180 | Complete | BTSP | Y | ||
| OC-133 | 172051070 | Complete | Hypothetical secreted peptide precursor | Y | ||
|
Cytotoxin family | ||||||
| OC-574 | 172051198 | Truncated | Putative salivary secreted protein | Y | ||
|
Glycine-rich protein family | ||||||
| OC-130 | 172051066 | Complete | Putative secreted glycine-rich salivary protein | Y | ||
|
7DB family unique to Argasidae | ||||||
| OC-104 | 172051050 | Complete | 7DB family | |||
| OC-120 | 172051060 | Complete | 7DB family | Y | ||
| OC-106 | 172051054 | Complete | 7DB family | Y | ||
|
Peptides of the 8-kDa family | ||||||
| OC-98 | 172051254 | Complete | Hypothetical secreted peptide precursor | |||
| OC-194 | 172051088 | Complete | Hypothetical secreted peptide precursor | |||
|
Unique Ornithodoros families | ||||||
| OC-64 | 172051214 | Complete | Hypothetical secreted peptide precursor | Y | ||
|
Disulphide-rich 5-kDa family | ||||||
| OC-93 | 172051248 | Complete | Putative salivary secreted peptide | |||
| OC-129 | 172051064 | Complete | Hypothetical secreted peptide precursor | |||
|
Novel families | ||||||
| OC-724 | 172051226 | Complete | Hypothetical secreted peptide precursor | |||
| OC-458 | 172051158 | Complete | Hypothetical secreted peptide precursor | |||
| OC-46 | 172051160 | Complete | Hypothetical secreted peptide precursor | |||
| OC-520 | 172051184 | Complete | Hypothetical secreted peptide precursor | |||
| OC-639 | 172051212 | Complete | Hypothetical secreted peptide precursor | |||
| OC-73 | 172051228 | Complete | Hypothetical secreted peptide precursor | |||
| OC-97 | 172051252 | Complete | Hypothetical secreted peptide precursor | |||