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. 2009 Jan 14;4(1):e4186. doi: 10.1371/journal.pone.0004186

Figure 1. Decreased arthritis incidence and severity after HSP70 immunization.

Figure 1

Mice were injected intraperitoneally, 10 days prior to disease induction, with either 100 µg recombinant microbial heat shock protein 70 (HSP70) or 100 µg enhanced green fluorescent protein (EGFP) both emulsified in synthetic adjuvant DDA or with PBS. Arthritis was induced by two immunizations of proteoglycan (PG) in DDA on day 0 and 21. (A) Arthritis incidence is expressed as the cumulative percentage of arthritic animals and (B) arthritis severity is expressed as the mean arthritis score of sick mice±SEM. Data are representative of three independent experiments (n = 10 in each group).