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. 1996 Dec 10;93(25):14648–14653. doi: 10.1073/pnas.93.25.14648

Figure 4.

Figure 4

Evolutionary tree that describes the hypothetical emergence of H. pylori type I as a result of an event of gene conversion (PAI acquisition). Presumably, it is only after the integration of an IS605 that subpopulations of intermediate strains with attenuated virulence are differentiated. cag retention is indicated by arrows. Type II strains are distinguishable from type I strains with a complete cag deletion by the absence of IS605. The following strains have the genotypes listed in the tree. Genotypes: 1, G11, G33, G46, G89, G103, G109, 932, Ba99, Ba 137, and Ba158; 2, CCUG 17874, G32, G56, G106, and G204; 3, 60190, G20, G27, G29, G65, Ba179, and Ba 211; 4, G39, D933, Ba167, Ba182, Ba194, and Ba212; 5, G12 and G25; 6, G104 and D925; 7, Tx30a and G50; 8, Ba82, Ba142, G21, G198, 2U+, and 2U-.