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. 1996 Dec 10;93(25):14659–14664. doi: 10.1073/pnas.93.25.14659

Figure 1.

Figure 1

Diagram of mouse histone H2A pre-mRNA and human U7 RNA mutants. Partial sequence of the mouse histone H2A pre-mRNA (4), indicating the wild-type cleavage site, the site of insertions, the HDE residues that base pair to the U7 RNA, and the residues altered in the base substitution mutants. All histone pre-mRNA substrates contain an additional 14 nt of vector sequence at the 5′ end. The human U7 sequence (5) is shown with the Sm site shaded. Partial sequences of the base substitution HDE and U7 RNA suppressor mutants (6) are shown with altered residues dipicted below the wild-type sequence. Residues involved in base pairing to the U7 RNA or the histone pre-mRNA are underlined with G·U base pairs indicated by dots.