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LPG lowers the stability of IL-1β mRNA. (A) IL-1β mRNA stability after LPS or LPS/LPG treatment, and the amount of IL-1β mRNA present at 2 h. Each condition was taken as the reference for comparison of residual IL-1β mRNA at the later times (mean of three or four experiments; SD < 10% the of mean). (B) Representative autoradiograph of the effect of LPG on mRNA levels of IL-1β and GAPDH. Lanes: 1–8, LPS at 2 μg/ml; 5–8, 2 μM LPG.
