Table 2. Hu-PBL-SCID Models of Autoimmunity.
Human autoimmune diseases modeled in humanized Hu-PBL-SCID mice.
| Autoimmune Disease | Target Tissue | Reference |
|---|---|---|
| Type 1 Diabetes | Islets/Beta Cells | 20 |
| Primary Biliary Cirrhosis | Liver | 25 |
| Multiple Sclerosis | Central Nervous System | 19 |
| Autoimmune Thyroid Disease | Thyroid | 21 |
| Rheumatoid Arthritis | Joint Synovium | 22 |
| Psoriasis | Skin | 26 |
| Systemic Lupus Erythematosus | Autoantibodies, multiple targets | 27 |
| Myasthenia Gravis | Acetylcholine Receptors | 28 |
| Autoimmune Hemolytic Anemia | Erythrocytes | 29 |
| Pemphigus Vulgaris | Skin | 30 |